A. Petrucci et al., HOW MANY HIV-INFECTED INDIVIDUALS MAY BE DEFINED AS LONG-TERM NONPROGRESSORS - A REPORT FROM THE ITALIAN SEROCONVERSION STUDY, Journal of acquired immune deficiency syndromes and human retrovirology, 14(3), 1997, pp. 243-248
We prospectively examined a cohort of HIV-positive persons with an acc
urately estimated date of HIV seroconversion who were infected through
injecting drug use or sexual contact to estimate the proportion of lo
ng-term nonprogressors (LTNP), considering four definitions of LTNPs.
We also evaluated whether factors such as gender, age, and HIV-exposur
e category were associated with being LTNP; we determined the overlap
among the definitions and compared the CD4 and CD8 counts and the CD4/
CD8 decline among LTNPs and ''moderate'' and ''fast'' progressors. Of
the 528 persons selected for analysis, 2 to 4% were considered LTNPs,
depending on the definition. The proportion of LTNPs varied by definit
ion, and there was little overlap among definitions. The LTNPs did not
appear to differ from ''moderate'' and ''fast'' progressors with rega
rd to main demographic characteristics, and they showed a better trend
of immunological parameters, appearing to have a slower progression r
ather than a permanently arrested infection.