PREPARATION OF NAPHTHOQUINONE DERIVATIVES FROM PLUMBAGIN AND THEIR ICHTHYOTOXICITY

Authors
OGIHARA K YAMASHIRO R HIGA M YOGI S
Citation
K. Ogihara et al., PREPARATION OF NAPHTHOQUINONE DERIVATIVES FROM PLUMBAGIN AND THEIR ICHTHYOTOXICITY, Chemical and Pharmaceutical Bulletin, 45(3), 1997, pp. 437-445
Citations number
29
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
3
Year of publication
1997
Pages
437 - 445
Database
ISI
SICI code
0009-2363(1997)45:3<437:PONDFP>2.0.ZU;2-V
Abstract
Various naphthoquinone derivatives were prepared from a natural produc t, 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin); these were mostl y substituted at C-3 through carbon-carbon bond formation mediated by a metal-based oxidant such as lead tetraacetate in the presence of var ious carboxylic acids. The halogenated compounds showed stronger ichth yotoxicity than plumbagin, but other derivatives were less active.