REACTIVITIES OF 6-AMINO-1,3-DIMETHYL-5-THIOFORMYLURACIL TOWARD NUCLEOPHILES AND ITS APPLICATION TO SYNTHESIS OF PYRIDO[2,3-D]PYRIMIDINES

Authors
HIROTA K KUBO K SAJIKI H
Citation
K. Hirota et al., REACTIVITIES OF 6-AMINO-1,3-DIMETHYL-5-THIOFORMYLURACIL TOWARD NUCLEOPHILES AND ITS APPLICATION TO SYNTHESIS OF PYRIDO[2,3-D]PYRIMIDINES, Chemical and Pharmaceutical Bulletin, 45(3), 1997, pp. 542-544
Citations number
34
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
3
Year of publication
1997
Pages
542 - 544
Database
ISI
SICI code
0009-2363(1997)45:3<542:RO6TN>2.0.ZU;2-2
Abstract
The reaction of the 5-thioformyluracil 1 with phenylhydrazine and vari ous amines readily afforded the hydrazone 3a and Schiff bases 3b-d, re spectively. Further, carbanions and Wittig reagents reacted with 1 to give pyrido[2,3-d]pyrimidines 4 and 9. The corresponding 5-formyluraci l 2 possessed much lower reactivities toward these nucleophiles than d id 1.