CYTOPROTECTIVE EFFECTS OF 4,6-BIS(1H-PYRAZOL-1-YL)PYRIMIDINE AND RELATED-COMPOUNDS ON HCL-CENTER-DOT-ETHANOL-INDUCED GASTRIC-LESIONS IN RATS

Authors
IKEDA M MARUYAMA K NOBUHARA Y YAMADA T OKABE S
Citation
M. Ikeda et al., CYTOPROTECTIVE EFFECTS OF 4,6-BIS(1H-PYRAZOL-1-YL)PYRIMIDINE AND RELATED-COMPOUNDS ON HCL-CENTER-DOT-ETHANOL-INDUCED GASTRIC-LESIONS IN RATS, Chemical and Pharmaceutical Bulletin, 45(3), 1997, pp. 549-551
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
3
Year of publication
1997
Pages
549 - 551
Database
ISI
SICI code
0009-2363(1997)45:3<549:CEO4AR>2.0.ZU;2-J
Abstract
Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthe sized and evaluated for cytoprotective effects. Among them, 4,6-bis(1H -pyrazol-1-yl)pyrimidine (3) showed a potent inhibitory effect on the HCl . ethanol-, ethanol-, and water immersion stress-induced gastric l esions in rats, and a very low acute toxicity. One of the major factor s responsible for the cytoprotective effects of 3 is the increase in t he bicarbonate secretion. This compound appears to be a promising cyto protective drug for the treatment of gastric mucosal ulcers.