M. Ikeda et al., CYTOPROTECTIVE EFFECTS OF 4,6-BIS(1H-PYRAZOL-1-YL)PYRIMIDINE AND RELATED-COMPOUNDS ON HCL-CENTER-DOT-ETHANOL-INDUCED GASTRIC-LESIONS IN RATS, Chemical and Pharmaceutical Bulletin, 45(3), 1997, pp. 549-551
Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthe
sized and evaluated for cytoprotective effects. Among them, 4,6-bis(1H
-pyrazol-1-yl)pyrimidine (3) showed a potent inhibitory effect on the
HCl . ethanol-, ethanol-, and water immersion stress-induced gastric l
esions in rats, and a very low acute toxicity. One of the major factor
s responsible for the cytoprotective effects of 3 is the increase in t
he bicarbonate secretion. This compound appears to be a promising cyto
protective drug for the treatment of gastric mucosal ulcers.