REPLACEMENT OF THE 1',4'-PHENYLENE REGION IN 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID (DDATHF) BY 4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE AND 4,5,6,7-TETRAHYDROISOBENZOFURAN NUCLEI
Ec. Taylor et Je. Dowling, REPLACEMENT OF THE 1',4'-PHENYLENE REGION IN 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID (DDATHF) BY 4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE AND 4,5,6,7-TETRAHYDROISOBENZOFURAN NUCLEI, Journal of organic chemistry, 62(6), 1997, pp. 1599-1603
Two new analogs of DDATHF, in which the 1',4'-phenylene unit is replac
ed by 4,5,6,7-tetrahydrobenzo[c]thiophene and 4,5,6,7-tetrahydroisoben
zofuran nuclei, have been prepared and evaluated for in vitro cytotoxi
city, GARFT inhibition, and FPGS affinity as potential antitumor agent
s.