REPLACEMENT OF THE 1',4'-PHENYLENE REGION IN 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID (DDATHF) BY 4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE AND 4,5,6,7-TETRAHYDROISOBENZOFURAN NUCLEI

Authors
TAYLOR EC DOWLING JE
Citation
Ec. Taylor et Je. Dowling, REPLACEMENT OF THE 1',4'-PHENYLENE REGION IN 5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID (DDATHF) BY 4,5,6,7-TETRAHYDROBENZO[C]THIOPHENE AND 4,5,6,7-TETRAHYDROISOBENZOFURAN NUCLEI, Journal of organic chemistry, 62(6), 1997, pp. 1599-1603
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
62
Issue
6
Year of publication
1997
Pages
1599 - 1603
Database
ISI
SICI code
0022-3263(1997)62:6<1599:ROT1RI>2.0.ZU;2-W
Abstract
Two new analogs of DDATHF, in which the 1',4'-phenylene unit is replac ed by 4,5,6,7-tetrahydrobenzo[c]thiophene and 4,5,6,7-tetrahydroisoben zofuran nuclei, have been prepared and evaluated for in vitro cytotoxi city, GARFT inhibition, and FPGS affinity as potential antitumor agent s.