BATZELLADINES F-I, NOVEL ALKALOIDS FROM THE SPONGE BATZELLA SP - INDUCERS OF P56(LCK)-CD4 DISSOCIATION

Authors
PATIL AD FREYER AJ TAYLOR PB CARTE B ZUBER G JOHNSON RK FAULKNER DJ
Citation
Ad. Patil et al., BATZELLADINES F-I, NOVEL ALKALOIDS FROM THE SPONGE BATZELLA SP - INDUCERS OF P56(LCK)-CD4 DISSOCIATION, Journal of organic chemistry, 62(6), 1997, pp. 1814-1819
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
62
Issue
6
Year of publication
1997
Pages
1814 - 1819
Database
ISI
SICI code
0022-3263(1997)62:6<1814:BFNAFT>2.0.ZU;2-M
Abstract
The sponge Batzella sp, from Jamaica contains four new alkaloids, batz elladines F-I(1-4), that induce the p56(lck)-CD4 dissociation. Batzell adines F-I were isolated using a bioassay-directed fractionation schem e and were identified by interpretation of spectroscopic data, Batzell adines F, G, and H + I were active in the p56(lck)-CD4 dissociation as say at micromolar concentrations.