PRESYNAPTIC INHIBITION BY SEROTONIN - A POSSIBLE MECHANISM FOR SWITCHING MOTOR OUTPUT OF THE HYPOGLOSSAL NUCLEUS

Authors
SINGER JH BERGER AJ
Citation
Jh. Singer et Aj. Berger, PRESYNAPTIC INHIBITION BY SEROTONIN - A POSSIBLE MECHANISM FOR SWITCHING MOTOR OUTPUT OF THE HYPOGLOSSAL NUCLEUS, Sleep, 19(10), 1996, pp. 146-149
Citations number
28
Categorie Soggetti
Behavioral Sciences","Clinical Neurology
Journal title
Sleep → ACNP
ISSN journal
01618105
Volume
19
Issue
10
Year of publication
1996
Supplement
S
Pages
146 - 149
Database
ISI
SICI code
0161-8105(1996)19:10<146:PIBS-A>2.0.ZU;2-H
Abstract
We examined the influence of serotonin (5-HT), an important state-depe ndent neuromodulator, on synaptic transmission to hypoglossal motoneur ons (HMs). Our data demonstrate that 5-HT acts presynaptically to inhi bit excitatory (glutamatergic) synaptic currents recorded in HMs. We d iscuss this result in relation to the role of 5-HT in state-dependent modulation of respiration-related activity in HMs.