URINARY-EXCRETION OF DEPRENYL METABOLITES

(-)-Deprenyl metabolites in rat's urine, such as nordeprenyl, methamph etamine, amphetamine and p-hydroxy methamphetamine were identified by HPLC-MS. After oral administration of 10 mg of pure (-)- and (-)-depre nyl to human volunteers, their urine was analyzed by gas chromatograph y. The concentration of methamphetamine was found to be overwhelming i n the case of the (-)-isomer, while amphetamine and methamphetamine we re excreted in equal amounts when (+)-deprenyl was administered. The m etabolic processes of deprenyl resulted in metabolites possessing diff erent lipophilicity, as it has been shown by planar displacement chrom atography.