BRAIN PENETRATION AND NEUROLOGICAL EFFECTS OF GADOBENATE DIMEGLUMINE IN THE RAT

Citation
F. Luzzani et al., BRAIN PENETRATION AND NEUROLOGICAL EFFECTS OF GADOBENATE DIMEGLUMINE IN THE RAT, Acta radiologica, 38(2), 1997, pp. 268-272
Citations number
26
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
ISSN journal
02841851
Volume
38
Issue
2
Year of publication
1997
Pages
268 - 272
Database
ISI
SICI code
0284-1851(1997)38:2<268:BPANEO>2.0.ZU;2-Q
Abstract
Purpose: The study aimed at measuring the amount of the gadobenate ion that crosses an experimentally disrupted blood-brain barrier (BBB) in rats following i.v. administration of gadobenate dimeglumine (GD). Th e intention was also to compare this amount with the minimally effecti ve intrathecal dose that alters the cerebral function. Methods: Spragu e Dawley rats with an osmotically disrupted BBB received 0.3 mmol/kg o f (Gd-153)GD, i.v. Radioactivity was measured in plasma and brain pare nchyma. The effect on the cerebral function was evaluated by means of a standard motor coordination test (Rota-rod test). Results: Brain lev els of the gadobenate ion were approximately 60 nmol/g tissue after i. v. injection of GD. In rats with an intact BBB, the lowest dose of GD able to slightly impair motor coordination was 0.01 mmol/kg following intracisternal injection. Conclusion: I.v. administration of GD to rat s with a disrupted BBB results in brain levels of the gadobenate ion t hat are more than 20 times lower than those reached following intrathe cal administration of the minimal effective dose, as determined by the Rota-rod test.