ADJUVANT CHEMOTHERAPY (5-FLUOROURACIL AND LEVAMISOLE) IN DUKES-B AND DUKES-C COLORECTAL-CARCINOMA - A COST-EFFECTIVENESS ANALYSIS

Background: Adjuvant chemotherapy (5-fluorouracil, levamisole) is now standard practice in the treatment of Dukes' B and C coloretal carcino ma (CRC), and this has increased the financial burden on health care s ystems world-wide. Patients and methods: Between 1993 and 1996, 95 pat ients in northern Norway were included in a national randomised CRC st udy, and assigned to surgery plus adjuvant chemotherapy or surgery alo ne. In April 1996, 94 of the patients were evaluable and 82 were still alive. The total treatment costs (hospital stay, surgery, chemotherap y, administrative and travelling costs) were calculated. A questionnai re was mailed to all survivors for assessment of the quality of their lives (QoL) (EuroQol questionnaire, a simple QoL-scale, global QoL-mea sure of the EORTC QLQ-C30), and 62 of them (76%) responded. Results: A djuvant chemotherapy in Dukes' B and C CRC raised the total treatment costs by pound 3,360. The median QoL was 0.83 (0-1 scale) in both arms . Employing a 5% discount rate and an improved survival of adjuvant th erapy ranging from 5% to 15%, we calculated the cost of one gained qua lity-adjusted life-year (QALY) to be between pound 4,800 and pound 16, 800. Conclusion: Using a cut-off point level of pound 20,000 per QALY, adjuvant chemotherapy in CRC appears to be cost-effective only when t he improvement in 5-year survival is greater than or equal to 5%. Adju vant chemotherapy does not affect short-term QoL.