STUDY OF THE INFLUENCE OF MACROMOLECULAR ADHESIVE FACTORS, ISOLATED FROM SERUM AND LIVER, ON THE INTENSITY OF PROTEIN-SYNTHESIS AS WELL AS ON THE ATP CONTENTS IN HEPATOCYTES IN-VITRO

The influence of the extra-low dozes of the macromolecular adhesive fa ctors (MAF) on the protein synthesis and on the ATP contents in the ra t hepatocytes on different models in vitro has been investigated. The protein synthesis intensity, the cell penetrability for labelled H-3-l eucine and the intracell ATP contents in the experiments with the hepa tocyte monolayer in control cells has been showed to be the same as th ose in the cells treated by MAF-1 and MAF-2. In the liver cells the pr otein synthesis intensity was depressed essentially under the action o f MAF-1 and MAF-2 with respect to the control cells. The penetrability . of the liver cells has increased in 50% of experiments after MAF-1 a nd MAF-2 treatment. The data obtained show the necessity. of preservat ion of morphological structure of organs for the realization of the bi ological activity of appropriate MAF.