VARIABLE EFFECTS OF IODINATED CONTRAST-MEDIA ON DIFFERENT RABBIT ARTERIES IN-VITRO

Citation
D. Rauch et al., VARIABLE EFFECTS OF IODINATED CONTRAST-MEDIA ON DIFFERENT RABBIT ARTERIES IN-VITRO, Urological research, 25, 1997, pp. 21-23
Citations number
14
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
03005623
Volume
25
Year of publication
1997
Supplement
1
Pages
21 - 23
Database
ISI
SICI code
0300-5623(1997)25:<21:VEOICO>2.0.ZU;2-9
Abstract
Vasoconstriction caused by iodinated contrast media (CM) has been cons idered specific for the renal ar artery only. We examined the vascular effect of CM in rabbit carotid, aorta, renal, iliac, mesenteric and c eliac arteries and found that other arteries also respond with a contr action to CM. Isolated arterial rings were exposed to diatrizoate (hig h osmolar CM), iohexol (low osmolar CM) or glucose solution, and the i sometric contraction response was expressed as percentage of an initia l KCl control contraction. Diatrizoate evoked contractions of 82% (car otid), 63% (aorta), 30% (renal), 24% (iliac), 28% (mesenteric) and 18% (celiac), respectively. Iohexol caused contractions of 31% (carotid), 24% (aorta), 15% (renal) and 14% (iliac), whereas the mesenteric and celiac arteries were relaxed by iohexol. A high osmolar glucose soluti on elicited contractions of 78%, 77%, 11%, 27%, 3% and 5%, respectivel y, in the arteries. CM have contraction potency in arterial vasculatur e other than the renal artery.