EFFECTS OF DIETARY BROCCOLI ON HUMAN DRUG-METABOLIZING ACTIVITY

Authors
KALL MA VANG O CLAUSEN J
Citation
Ma. Kall et al., EFFECTS OF DIETARY BROCCOLI ON HUMAN DRUG-METABOLIZING ACTIVITY, Cancer letters, 114(1-2), 1997, pp. 169-170
Citations number
4
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
114
Issue
1-2
Year of publication
1997
Pages
169 - 170
Database
ISI
SICI code
0304-3835(1997)114:1-2<169:EODBOH>2.0.ZU;2-M
Abstract
Eighteen volunteers received 500 g fresh broccoli every day for 12 day s after a 6-day period of standard diet. The activity of CYP1A2, CYP2E 1 and the estrone 2 and 16 alpha-hydroxylation were determined prior t o and after the broccoli diet. The average activity of CYP1A2 and the average 2/16 alpha-hydroxyestrone ratio were increased 19% (P < 0.0005 ) and 29.5% (P < 0.05), respectively; however, no effects were observe d on the CYP2E1 activity. (C) 1997 Elsevier Science Ireland Ltd.