SWINHOSTEROLS A-C, 4-METHYLENE SECOSTEROIDS FROM THE MARINE SPONGE THEONELLA-SWINHOEI

Authors
UMEYAMA A SHOJI N ENOKI M ARIHARA S
Citation
A. Umeyama et al., SWINHOSTEROLS A-C, 4-METHYLENE SECOSTEROIDS FROM THE MARINE SPONGE THEONELLA-SWINHOEI, Journal of natural products, 60(3), 1997, pp. 296-298
Citations number
10
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
3
Year of publication
1997
Pages
296 - 298
Database
ISI
SICI code
0163-3864(1997)60:3<296:SA4SFT>2.0.ZU;2-G
Abstract
Three 4-methylene steroids, named swinhosterols A-C (1-3) were isolate d from the Okinawan sponge Theonella swinhoei Gray. The structures of 1 and 2, which combine rare 4-methylene and seco features, were determ ined as (24S)-3 beta-hydroxy-24-ethyl-4-methylene-5 alpha-8,14-secocho lestane-8,14-dione and (24R)-3 beta-hydroxy-24-methyl-4-methylene-5 al pha,14-secocholestane-8,14-dione, and the structure of 3 was determine d as (24S)-24-ethyl-7-methoxy-4-methylene-5 alpha-cholest-8(14)-en-3 b eta-ol on the basis of spectroscopic investigations.