IN-VITRO CONVERSION OF 2,3-OXIDOSQUALENE INTO DAMMARENEDIOL BY PANAX-GINSENG MICROSOMES

Authors
KUSHIRO T OHNO Y SHIBUYA M EBIZUKA Y
Citation
T. Kushiro et al., IN-VITRO CONVERSION OF 2,3-OXIDOSQUALENE INTO DAMMARENEDIOL BY PANAX-GINSENG MICROSOMES, Biological & pharmaceutical bulletin, 20(3), 1997, pp. 292-294
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
20
Issue
3
Year of publication
1997
Pages
292 - 294
Database
ISI
SICI code
0918-6158(1997)20:3<292:ICO2ID>2.0.ZU;2-S
Abstract
(RS)-[3-H-3]-2,3-Oxidosqualene (1) was converted into (20S)-dammarened iol (2) and not to (20R)-dammarenediol by a microsomal fraction prepar aed from the hairy root of Panax ginseng. The enzyme activity was high est at pH 6.0 and was not increased by the addition of any detergents. These properties differed significantly from those of other 2,3-oxido squalene cyclases reported from higher plants and animals.