ANALYSIS OF THE MUTAGENIC POTENTIAL OF ENU AND MMS IN GERM-CELLS OF MALE C57BL 6 LACI TRANSGENIC MICE/

Authors
WINEGAR RA CARR G MIRSALIS JC
Citation
Ra. Winegar et al., ANALYSIS OF THE MUTAGENIC POTENTIAL OF ENU AND MMS IN GERM-CELLS OF MALE C57BL 6 LACI TRANSGENIC MICE/, Mutation research. Genetic toxicology and environmental mutagenesis, 388(2-3), 1997, pp. 175-178
Citations number
5
Categorie Soggetti
Toxicology,"Genetics & Heredity
Journal title
Mutation research. Genetic toxicology and environmental mutagenesis → ACNP
ISSN journal
13835718
Volume
388
Issue
2-3
Year of publication
1997
Pages
175 - 178
Database
ISI
SICI code
1383-5718(1997)388:2-3<175:AOTMPO>2.0.ZU;2-6
Abstract
Mutant frequencies in male germ cells were determined in mice 3 days a fter exposure to saline, methylmethane sulfonate (MMS), or ethylnitros ourea (ENU). DNA was isolated from seminiferous tubules by a modified version of the drop dialysis method. A 5-fold increase in mutant frequ ency was observed in mice treated with ENU, No statistically significa nt increase was observed in mice treated with MMS.