LOCOREGIONAL CHEMOTHERAPY OF GYNECOLOGICAL CANCER

Background: Locoregional chemotherapy can be considered in patients wi th a previously treated local recurrencies. A necessary condition is t he sufficient perfusion of the tumor and the surrounding tissue throug h the catheter. Patients and Methods: After exclusion of distant metas tases, 5 patients with genital carcinoma infiltrating the pelvic wall and 5 patients with breast cancer infiltrating the chest wall followin g boast cancer surgery were given locoregional chemotherapy. The locat ion of the catheter was controlled by spiral CT and angiography. Mitox antron and mitomycin were administered. Heparinization was performed f or 24 h to prevent thrombosis. Results: The 10 patients responded to t he locoregional chemotherapy. Pain symptoms and the clinical findings improved considerably. Finally, all patients died of generalized disea se. Conclusion: Results of locoregional perfusion chemotherapy depend on primary tumors and pretreatment. However, it could be demonstrated on 10 patients that a beneficial palliative effect can be reached in p atients for whom there is no further therapy.