RELATIONSHIP BETWEEN STRUCTURE AND CHROMATOGRAPHIC BEHAVIOR OF SECONDARY ALCOHOLS AND THEIR DERIVATIVES SEPARATED BY HIGH-RESOLUTION GAS-CHROMATOGRAPHY WITH A MODIFIED BETA-CYCLODEXTRIN STATIONARY-PHASE

Low-boiling secondary alcohols (2-butanol, 2-pentanol and 2- and 3-hex anol) and their methyl, pentyl, acetyl and trifluoroacetyl derivatives were separated by gas chromatography on a fused-silica capillary colu mn coated with a mixture of OV-1701 and heptakis yldimethylsilyl-2,3-d i-O-acetyl)-beta-cyclodextrin (1:1) The retention of these solutes was studied by determining their separation factors (alpha) and this temp erature dependences. The retention of enantiomers was correlated with optical activity and structural data obtained by theoretical calculati ons. It was demonstrated that the separation of enantiomers on a modif ied cyclodextrin stationary phase is governed inter alia by total mole cule asymmetries.