H. Grudemo et Je. Juto, RHINOSTEREOMETRY AND LASER-DOPPLER FLOWMETRY IN HUMAN NASAL-MUCOSA - CHANGES IN CONGESTION AND MICROCIRCULATION DURING INTRANASAL HISTAMINECHALLENGE, ORL, 59(1), 1997, pp. 50-56
The nasal mucosa of 10 healthy volunteers was studied with the combina
tion of rhinostereometry and laser Doppler flowmetry during a challeng
e with 0.14 mi histamine dihydrochloride in stepwise increasing concen
trations of 0.5, 1.0, 2.0, 4.0, 8.0 and 16.0 mg/ml. Five and 10 min af
ter each challenge the degree of congestion and the microcirculatory p
arameters perfusion, velocity of flow and concentration of moving bloo
d cells were recorded. A complex reaction pattern was seen. It was pos
sible to measure simultaneously the degree of congestion and the micro
circulatory parameters. With this combination of methods, it seemed po
ssible to identify the effects of histamine on the different component
s of the nasal mucosa. The combination of the two methods appears to m
ake possible detailed studies of the relationship between changes in c
ongestion and microcirculation during intranasal challenges in humans.