LYSOSOMAL MEMBRANE STABILIZATION BY ALPHA-TOCOPHEROL AGAINST THE DAMAGING ACTION OF VIPERA-RUSSELLI VENOM PHOSPHOLIPASE A(2)

Authors
MUKHERJEE AK GHOSAL SK MAITY CR
Citation
Ak. Mukherjee et al., LYSOSOMAL MEMBRANE STABILIZATION BY ALPHA-TOCOPHEROL AGAINST THE DAMAGING ACTION OF VIPERA-RUSSELLI VENOM PHOSPHOLIPASE A(2), Cellular and molecular life sciences, 53(2), 1997, pp. 152-155
Citations number
22
Categorie Soggetti
Biology,"Cell Biology",Biology
Journal title
Cellular and molecular life sciences → ACNP
ISSN journal
1420682X
Volume
53
Issue
2
Year of publication
1997
Pages
152 - 155
Database
ISI
SICI code
1420-682X(1997)53:2<152:LMSBAA>2.0.ZU;2-Y
Abstract
This investigation shows the membrane stabilizing effect of alpha-toco pherol against the damaging action of viper venom phospholipase A(2) ( PLA(2)). Liver lysosomal membranes from rats fed 100 mg and 200 mg alp ha-tocopherol acetate per kilogram of diet were more resistant to dama ge by viper venom PLA(2) compared with vitamin E-deficient rats. The m embrane stabilizing effect of vitamin E is proposed to be due to the f ormation of a complex with the phospholipid hydrolysis products of the membrane.