EVALUATION OF A NEW MACROCYCLIC ANTIBIOTIC AS A CHIRAL SELECTOR FOR USE IN CAPILLARY ELECTROPHORESIS

Authors
SHARP VS RISLEY DS MCCARTHY S HUFF BE STREGE MA
Citation
Vs. Sharp et al., EVALUATION OF A NEW MACROCYCLIC ANTIBIOTIC AS A CHIRAL SELECTOR FOR USE IN CAPILLARY ELECTROPHORESIS, Journal of liquid chromatography & related technologies, 20(6), 1997, pp. 887-898
Citations number
40
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of liquid chromatography & related technologies → ACNP
ISSN journal
10826076
Volume
20
Issue
6
Year of publication
1997
Pages
887 - 898
Database
ISI
SICI code
1082-6076(1997)20:6<887:EOANMA>2.0.ZU;2-C
Abstract
A new macrocyclic antibiotic, LY307599, has been evaluated as a chiral selector for the separation of the enantiomers of flurbiprofen using capillary electrophoresis (CE). The effect of varying separation buffe r parameters such as buffer strength, pH, LY307599 concentration and m ethanol concentration were assessed. Using the optimized CE conditions , the separation of flurbiprofen enantiomers can be achieved using LY3 07599 as a chiral selector.