Qc. Chen et al., SEPARATION AND DETERMINATION OF ORGANOGERMANIUM COMPOUNDS BY ION CHROMATOGRAPHY, Journal of liquid chromatography & related technologies, 20(6), 1997, pp. 943-956
Citations number
17
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
For nearly three decades, organogermanium compounds have become increa
singly of interest owing to their extensive physiological and pharmace
utical activity. In this paper, two new high performance ion chromatog
raphic methods for separation and determination of three kinds of orga
nogermanium compounds beta-carboxyethylgermanium sesquioxide (I), beta
-(alpha-methyl)-carboxyethylgermanium sesquioxide (II) and d-(beta-car
boxyethyl)germanium hydroxide (III) were proposed. A Dionex DX-300 ion
chromatograph equipped with a Dionex FED-II pulsed electrochemical de
tector (conductivity mode), and a Dionex AI-450 chromatography worksta
tion was employed. The separation was achieved by using ion-exchange o
r ion-exclusion mechanism. The detection limits(S/N=3, expressed as ge
rmanium) for the three compounds were all below sub- mu g/mL level. Th
e methods have been applied to the analysis of tonic oral drinks, and
the average recoveries for the three compounds range from 95 - 108%. T
he results obtained were in agreement with those of hydride generation
atomic fluorescence spectrometry (HG-AFS).