PARATHORMONE, 1,25-DIHYDROXYVITAMIN-D AND PROSTAGLANDIN E(2) CORRELATION IN CHILDREN WITH IDIOPATHIC HYPERCALCIURIA

As urinary prostaglandin excretion might be involved in idiopathic hyp ercalciuria, we studied the excretion of prostaglandin E(2) and calciu m together with serum prostaglandin E(2), parathormone and 1,25 dihydr oxyvitamin D in 20 patients and 11 controls Idiopathic hypercalciuric patients showed increased levels of urinary prostaglandin E(2)-like ac tivity, which is correlated with calcium excretion. Although no change was observed in serum parathormone level in control and hypercalciuri c patients, there was a positive correlation between serum 1,25 dihydr oxyvitamin D and prostaglandin E(2)-like activity. These findings sugg est that prostaglandin E(2) could play a role in the hypercalciuria sy ndrome, possibly by increasing 1,25 dihydroxyvitamin D synthesis.