We describe an HIV-negative homosexual man who developed Kaposi's sarc
oma (KS). He had CD4 lymphocytopenia during azathioprine and topical c
orticosteroid therapy for atopic dermatitits (AD). KS was observed aft
er only 2 months of immunosuppressive therapy. No regression was obser
ved despite discontinuation of immunosuppressive therapy and normaliza
tion of the CD4+ cell count. This patient appears to be the first case
of KS associated with AD. Moreover, as our patient had been sexually
inactive for Ii years, this case raises the questions about the latenc
y and about the sexual transmission of a navel herpes-like virus (KHSH
V) recently detected in all forms of KS.