A dermoid cyst of the penis has not been documented previously in the
literature. We report a young Caucasian who had an important swelling
of the penis dating back several months. On examination a subcutaneous
mass on the dorsal aspect of the shaft and prepuce was present. A cut
aneous sinus discharging purulent material was also noted above the ma
ss. Laboratory tests including serology for syphilis and bacteriologic
examination were negative. An excisional biopsy revealed a nodular le
sion in the subcutaneous tissue with tufts of hair emerging from the s
urface. Histopathologic examination disclosed granulation tissue conta
ining fragments of hair surrounded by granulomatous infiltrate. Serial
sections allowed identification of a subcutaneous cyst. The wall was
epidermoid and connected with several pilosebaceous units, A sinus tra
ct lined by stratified squamous epithelium contiguous with the epiderm
is was also noted. Clinical and histopathologic differential diagnoses
me discussed. Evidence for a congenital origin of this condition is g
iven.