ENHANCEMENT OF MICRONUCLEI FREQUENCY BY VINDESINE IN MOUSE BONE-MARROW

Authors
JAGETIA GC JYOTHI P
Citation
Gc. Jagetia et P. Jyothi, ENHANCEMENT OF MICRONUCLEI FREQUENCY BY VINDESINE IN MOUSE BONE-MARROW, Mutation research. Genetic toxicology and environmental mutagenesis, 388(1), 1997, pp. 1-5
Citations number
36
Categorie Soggetti
Toxicology,"Genetics & Heredity
Journal title
Mutation research. Genetic toxicology and environmental mutagenesis → ACNP
ISSN journal
13835718
Volume
388
Issue
1
Year of publication
1997
Pages
1 - 5
Database
ISI
SICI code
1383-5718(1997)388:1<1:EOMFBV>2.0.ZU;2-D
Abstract
Treatment of mice with Various doses (0, 0.25, 0.5, 1.0 and 2.0 mg/kg b.wt.) of vindesine resulted in a dose-dependent increase in the frequ ency of micronucleated polychromatic erythrocytes (MPCE) and micronucl eated normochromatic erythrocytes. Conversely, the polychromatic eryth rocyte and normochromatic erythrocyte (P/N ratio) ratio declined with increasing dose of vindesine. The dose effect relationship for MPCE, M NCE and P/N ratio was linear quadratic.