MORTALITY AMONG PATIENTS WITH ULCERATIVE-COLITIS - ROME 1970-1989

The aim of this study was to analyze the pattern of mortality among pa tients with ulcerative colitis (UC) and compare it with mortality in t he general population of the same age and sex. All patients with UC ad mitted to one of the Inflammatory Bowel Disease Clinics in Rome, from I January 1970 to December 31, 1989 were enrolled. Vital status was as certained through the Registry Office of the last municipality of resi dence as of. July 1, 1990. Cause of death was ascertained through reco rd linkage with the national or regional mortality file and coded usin g the ninth revision of the International Classification of Diseases. Standardized Mortality Ratios (SMRs) were computed to compare mortalit y among UC patients with mortality in the general population of the sa me age and sex. Out of a total of 508 UC patients admitted during the study period, 27 deaths were observed, compared with 27.6 expected (SM R = 98). After excluding prevalent cases, an excess risk of death was observed among newly diagnosed cases in the first year after diagnosis (SMR = 644; p < 0.001); ulcerative colitis was the main reason for th is excess mortality. Mortality for other diseases was close to that ex pected. In conclusion, ulcerative colitis impairs life expectancy in t he first year after diagnosis, while no excess mortality seems to be p resent afterwards.