DEVELOPING A GENERAL STRATEGY FOR THE SOLID SUPPORTED SYNTHESIS OF HETEROCYCLES - APPLICATIONS TO THE GENERATION OF MOLECULAR DIVERSITY ANDDRUG DISCOVERY

The development of a general strategy for the generation of molecular diversity in the form of novel, non-amide based heterocyclic structure s is described. The generation of diverse peptide and peptidemimetic l ibraries, the automation of these strategies and computational approac hes to diversity generation are also discussed. The main focus of this lecture is the the progression of these concepts into a strategy for small molecule library generation, and hence the generation of small m olecule therapeutic leads.