SEPARATION, DETERMINATION OF SOLUTE-MICELLE ASSOCIATION CONSTANTS, AND HYDROPHOBICITY QUANTITATION FOR A GROUP OF DIHYDROPYRIDINES BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY

Solute-micelle association constants for a group of 26 1,4-dihydropyri dines with sodium dodecyl sulfate micelles were determined by micellar electrokinetic chromatography with 2-(N-cyclohexylamino)-ethanesulfon ic acid as separation buffer in aqueous media and in the presence of a lcohols (n-propanol and n-butanol). Multicomponent mixtures of solutes were separated to reduce the time in measuring association constants. Hydrophobicity quantitation of 1,4-dihydropyridines from MEKC capacit y factors was performed. (C) John Wiley & Sons, Inc.