EFFECTS OF FRAXETIN ON GLUTATHIONE REDOX STATUS

We have evaluated the effects of an oral treatment of mice with fraxet in (25 mg/kg for 30 days) on the glutathione system (GSH, GSSG; and GS SG/GSH ratio as stress index), glutathione reductase (GR) and glutathi one peroxidase (GPx) in liver supernatants from male C57BL/6J mice (18 -month old). A significant antioxidant effect in vivo was found under this treatment by a decrease in the GSSG/GSH ratio and an increased ac tivity of GR compared with the control mice. GSSG rate and GSSG/GSH ra tio were correlated with the decline of GPx activity Our results of in creased GR activity could be considered as a supercompensation in glut athione redox status that involves a decrease in the accumulation of G SSG, as well as, in GSSG/GSH ratio. Finally we supercompensation could lead to an enhancement in the average life span.