ANTICOMPLEMENT ACTIVITY OF LYSINE COMPLEXES OF PROPOLIS PHENOLIC CONSTITUENTS AND THEIR SYNTHETIC ANALOGS

Several phenolic constituents of propolis and their synthetic analogs were derivatized with L-lysine. The ability of these complexes to alte r complement activity was estimated in vitro in human serum. The influ ence of selected complexes on C3 hemolytic activity via classical path way (CP) and alternative pathway (AP) and on zymosan-induced AP activa tion was determined. The results suppose that the anticomplement effec t of the complexes might be related to the interaction with C3 complem ent component.