ERYTHROCYTE HEMOLYSIS BY ORGANIC TIN AND LEAD COMPOUNDS

The effect of trialkyllead and trialkyltin on pig erythrocyte hemolysi s has been studied and compared. The results of experiments showed tha t the hemolytic activity of organoleads increases with their hydrophob icity and follows the sequence. triethyllead chloride < tri-n-propylle ad chloride < tributyllead chloride. And similarly in the case of orga notins: triethyltin chloride < tri-n-propyltin chloride < tributyltin chloride. Comparison of the hemolytic activity of organoleads and orga notins indicates that the lead compounds exhibit higher hemolytic acti vity The methods of quantum chemistry allowed to determine the maximum electric potential of the ions R(3)Pb(+) and R(3)Sn(+), and suggest a relationship between the potential and toxicity.