TOURETTE SYNDROME-ASSOCIATED WITH MENTAL-RETARDATION - A SINGLE-SUBJECT TREATMENT STUDY WITH HALOPERIDOL

A Tic Checklist and direct observation tic measurement procedure were developed for the assessment of Tourette syndrome in individuals with mental retardation. Using a single-subject reversal design, we applied this assessment method to the evaluation of haloperidol treatment for a subject with Tourette syndrome and severe mental retardation. Relat ive to baseline, haloperidol 10 mg/day produced decreases of 66% in si mple motor ties, 46% in complex motor ties, 45% in simple vocal ties, and 50% in complex vocal ties. Improvement was also seen in careprovid er ratings of tic severity, hyperactivity, and compulsive behaviors.