STUDY OF PATHOPHYSIOLOGY OF BARTTER GITELMANS SYNDROME - ATTEMPT OF CLASSIFICATION - ROLE OF RENAL MAGNESIUM DEPLETION/

Citation
Wb. Geven et al., STUDY OF PATHOPHYSIOLOGY OF BARTTER GITELMANS SYNDROME - ATTEMPT OF CLASSIFICATION - ROLE OF RENAL MAGNESIUM DEPLETION/, Magnesium-Bulletin, 16(1), 1994, pp. 29-36
Citations number
27
Categorie Soggetti
Biology
Journal title
ISSN journal
0172908X
Volume
16
Issue
1
Year of publication
1994
Pages
29 - 36
Database
ISI
SICI code
0172-908X(1994)16:1<29:SOPOBG>2.0.ZU;2-V
Abstract
Based on the concentrating ability and serum magnesium level it is pos sible to make a distinction between Bartter's syndrome, a defect local ized in the medullary part the thick ascending limb of the loop of Hen le and Gitelman's syndrome, a defect localized in the distal nephron a fter the medullary part of the ascending limb of the loop of Henle. A few patients, however, cannot be classified and are waiting for molecu lar approach in their disorders. From the fifteen investigated patient s seven had a lowered serum magnesium level. From these seven five had also a slightly reduced content of magnesium in the erythrocyte. The magnesium content of the mononuclear cells expressed as mu g/protein o r mu g/ DNA was normal in all patients. A pronounced magnesium deficie ncy was apparently not present in these group of patients.