NEW GENERAL-SYNTHESIS OF ORGANOPHOSPHORUS P-F COMPOUNDS VIA REACTION OF AZOLIDES OF PHOSPHORUS-ACIDS WITH ACYL FLUORIDES - NOVEL ROUTE TO 2-DEOXYNUCLEOSIDYL PHOSPHOROFLUORIDATES AND PHOSPHORODIFLUORIDATES
W. Dabkowski et al., NEW GENERAL-SYNTHESIS OF ORGANOPHOSPHORUS P-F COMPOUNDS VIA REACTION OF AZOLIDES OF PHOSPHORUS-ACIDS WITH ACYL FLUORIDES - NOVEL ROUTE TO 2-DEOXYNUCLEOSIDYL PHOSPHOROFLUORIDATES AND PHOSPHORODIFLUORIDATES, Journal of the Chemical Society. Perkin transactions. I, (7), 1994, pp. 817-820
Tetra- and tri-coordinate P-N-imidazole derivatives and their structur
al analogues react smoothly with acyl fluorides to give the correspond
ing P-F compounds in almost quantitative yield. This method has been s
uccessfully applied to produce 2-deoxynucleosidyl phosphorofluoridates
and phosphorodifluoridates.