NEW GENERAL-SYNTHESIS OF ORGANOPHOSPHORUS P-F COMPOUNDS VIA REACTION OF AZOLIDES OF PHOSPHORUS-ACIDS WITH ACYL FLUORIDES - NOVEL ROUTE TO 2-DEOXYNUCLEOSIDYL PHOSPHOROFLUORIDATES AND PHOSPHORODIFLUORIDATES

Authors
DABKOWSKI W MICHALSKI J WASIAK J CRAMER F
Citation
W. Dabkowski et al., NEW GENERAL-SYNTHESIS OF ORGANOPHOSPHORUS P-F COMPOUNDS VIA REACTION OF AZOLIDES OF PHOSPHORUS-ACIDS WITH ACYL FLUORIDES - NOVEL ROUTE TO 2-DEOXYNUCLEOSIDYL PHOSPHOROFLUORIDATES AND PHOSPHORODIFLUORIDATES, Journal of the Chemical Society. Perkin transactions. I, (7), 1994, pp. 817-820
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
7
Year of publication
1994
Pages
817 - 820
Database
ISI
SICI code
0300-922X(1994):7<817:NGOOPC>2.0.ZU;2-J
Abstract
Tetra- and tri-coordinate P-N-imidazole derivatives and their structur al analogues react smoothly with acyl fluorides to give the correspond ing P-F compounds in almost quantitative yield. This method has been s uccessfully applied to produce 2-deoxynucleosidyl phosphorofluoridates and phosphorodifluoridates.