TANDEM SILICA GEL-CATALYZED REARRANGEMENTS AND SUBSEQUENT BAEYER-VILLIGER REACTIONS OF ARTEMISININ DERIVATIVES

Authors
YAGEN B PU YM YEH HJC ZIFFER H
Citation
B. Yagen et al., TANDEM SILICA GEL-CATALYZED REARRANGEMENTS AND SUBSEQUENT BAEYER-VILLIGER REACTIONS OF ARTEMISININ DERIVATIVES, Journal of the Chemical Society. Perkin transactions. I, (7), 1994, pp. 843-846
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
7
Year of publication
1994
Pages
843 - 846
Database
ISI
SICI code
0300-922X(1994):7<843:TSGRAS>2.0.ZU;2-C
Abstract
Novel silica gel-catalysed reactions of dihydroartemisinin 1b to deoxy artemisinin 11 and 11 beta-hydroxy-11-epidihydroartemisinin 8 to compo und 9 under mild conditions are described. The structures of the produ cts were determined by mass spectrometry and 1D- and 2D-NMR spectrosco py. A mechanism for their formation is proposed.