KIDNEY-FUNCTION IN RATS AFTER 5 6-NEPHRECTOMY (5/6-NX) - EFFORT OF TREATMENT WITH VITAMIN-E/

In adult female rats various kidney functions were measured 3 weeks af ter 5/6 nephrectomy (5/6 NX). The distinct rises in blood urea nitroge n and in renal excretion of proteins indicate the impairment of the ki dney. In 5/6 NX rats, the renal excretion of creatinine, glucosaminogl ycan, and of p-aminohippurate was diminished. The concentrations of hy droxypyroline and of free hydrogen ions were distinctly increased in u rine samples from 5/6 NX rats. The concentration of lipid peroxides wa s enhanced in kidney tissue whereas 3 weeks after 5/6 NX the concentra tion of GSH and GSSG in the remnant kidney tissue was unchanged.Long-t erm administration of vitamin E increased its concentration in plasma, kidney, and liver. Nevertheless, daily treatment with vitamin E (1 or 10 mg/100 g b.w. s.c. for 5 weeks) did not reduce the degree of impai rment of kidney function following 5/6 NX.