D1-D2 DOPAMINE-RECEPTOR INTERACTION - AN IN-VIVO SINGLE-UNIT ELECTROPHYSIOLOGICAL STUDY

Citation
Mg. Murer et al., D1-D2 DOPAMINE-RECEPTOR INTERACTION - AN IN-VIVO SINGLE-UNIT ELECTROPHYSIOLOGICAL STUDY, NeuroReport, 8(3), 1997, pp. 783-787
Citations number
25
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
09594965
Volume
8
Issue
3
Year of publication
1997
Pages
783 - 787
Database
ISI
SICI code
0959-4965(1997)8:3<783:DDI-AI>2.0.ZU;2-J
Abstract
AFTER intrastriatal administration of selective dopamine receptor agon ists only a small percentage of substantia nigra pars reticulata singl e units showed changes in firing rate (23% after SKF38393 and 17% afte r quinpirole). After their intrastriatal co-administration, however, o r after the application of the non-selective dopamine receptor agonist apomorphine, 72% and 69% of units responded, respectively. This resul t confirms the participation of the striatum in the phenomenon of D1-D 2 receptor interaction, and show that co-activation of both receptor s ubtypes produced a maximal effect on basal ganglia output nuclei.