Children of substance abuse mothers have an increased risk of severe p
athological disorders such as perinatal diseases (prematurity, intraut
erine growth retardation, infections) with their neurological and resp
iratory complications and sequelae, and transmission of drug addiction
related infections, ie human immunodeficiency virus, hepatitis B and
C virus, syphilis. Many of these children present a drug withdrawal sy
ndrome characterized by restlessness and jetteriness during the neonat
al period. This is frequently followed by a post withdrawal period of
several weeks duration with crying, excitement, sleep and feeding diff
iculties. Although these drug withdrawal manifestations have no incide
nce on the vital prognosis, it severely impairs the mother-infant inte
raction. Despite these disorders it appears that the outcome of these
children is mainly related to their familial environment which is expo
sed to many risk factors: mother-child separation, violence, delinquen
cy, precariousness, unhealthy housing, prostitution, drug dependency,
parental death or imprisonment... Early medico-psycho-social intervent
ion starting during pregnancy and a prolonged support for several year
s are the only way to improve their spontaneously poor outcome.