THE ACTIVITIES AND SUBCELLULAR-LOCALIZATION OF CATHEPSIN-B AND CYSTEINE PROTEINASE-INHIBITORS IN HUMAN OVARIAN-CARCINOMA

Authors
HACZYNSKA H GERBER J OSADA J WARWAS M
Citation
H. Haczynska et al., THE ACTIVITIES AND SUBCELLULAR-LOCALIZATION OF CATHEPSIN-B AND CYSTEINE PROTEINASE-INHIBITORS IN HUMAN OVARIAN-CARCINOMA, Acta Biochimica Polonica, 44(1), 1997, pp. 113-120
Citations number
30
Categorie Soggetti
Biology
Journal title
Acta Biochimica Polonica → ACNP
ISSN journal
0001527X
Volume
44
Issue
1
Year of publication
1997
Pages
113 - 120
Database
ISI
SICI code
0001-527X(1997)44:1<113:TAASOC>2.0.ZU;2-T
Abstract
Ovarian carcinomas exhibited a higher cathepsin B activity than did no rmal ovaries. The plasma membrane fractions of ovarian cancers were en riched in the activities of both cathepsin and cysteine proteinase inh ibitors. The ratio of cathepsin to the inhibitors in these fractions w as higher at stage IV than at stage III of the disease, classified acc ording to the Federation of International Gynecology and Obstetrics.