COMPARISON BETWEEN DIETARY SOYBEAN PROTEIN AND CASEIN OF THE INHIBITING EFFECT ON ATHEROGENESIS IN THE THORACIC AORTA OF HYPERCHOLESTEROLEMIC (EXHC) RATS TREATED WITH EXPERIMENTAL HYPERVITAMIN-D
M. Sakono et al., COMPARISON BETWEEN DIETARY SOYBEAN PROTEIN AND CASEIN OF THE INHIBITING EFFECT ON ATHEROGENESIS IN THE THORACIC AORTA OF HYPERCHOLESTEROLEMIC (EXHC) RATS TREATED WITH EXPERIMENTAL HYPERVITAMIN-D, Bioscience, biotechnology, and biochemistry, 61(3), 1997, pp. 514-519
Atherosclerotic lesions of the thoracic aorta were induced in exogenou
sly hypercholesterolemic (ExHC) rats by treating initially with hyperv
itamin D-2 and subsequently feeding on hypercholesterolemic diets for
180 days, Dietary soybean protein, in comparison with casein, substant
ially decreased the degree of atherosclerotic lesions, which was evalu
ated by intimal thickening, although with a similar topographical dist
ribution, The casein-fed rats tended to maintain a high concentration
of serum cholesterol, particularly in triacylglycerol-rich lipoprotein
s. The concentrations of apo A-I and TEARS in the serum was comparable
between the dietary protein groups, The data suggest that dietary soy
bean protein, compared to casein, produced lipoproteins which were les
s atherosclerotic by partitioning cholesterol in the triacylglycerol-p
oor lipoproteins.