ISOLATION OF PROPIOXATIN-A FROM ACTINOSYNNEMA SP SI-23 DURING A SCREENING FOR SERRATIA-PISCATORUM METALLOPROTEINASE INHIBITORS

Authors
MURAO S IMAFUKU S OYAMA H
Citation
S. Murao et al., ISOLATION OF PROPIOXATIN-A FROM ACTINOSYNNEMA SP SI-23 DURING A SCREENING FOR SERRATIA-PISCATORUM METALLOPROTEINASE INHIBITORS, Bioscience, biotechnology, and biochemistry, 61(3), 1997, pp. 561-562
Citations number
13
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
61
Issue
3
Year of publication
1997
Pages
561 - 562
Database
ISI
SICI code
0916-8451(1997)61:3<561:IOPFAS>2.0.ZU;2-O
Abstract
An inhibitor of Serratia metalloproteinase was found in the cultured b roth of strain SI-23, which was identified to be Actinosynnema sp. The inhibitor had a potent inhibitory effect on Serratia metalloproteinas e and a weak effect on thermolysin, but no effect on other groups of p roteinases, The structure of the inhibitor was deduced to be propioxat in A, reported as an enkephalinase B inhibitor.