SYNTHESIS OF MICROCOLIN ANALOGS USING TRIMETHYLSILYLATED LACTAMS

Authors
MATTERN RH GUNASEKERA SP MCCONNELL OJ
Citation
Rh. Mattern et al., SYNTHESIS OF MICROCOLIN ANALOGS USING TRIMETHYLSILYLATED LACTAMS, Tetrahedron letters, 38(13), 1997, pp. 2197-2200
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
13
Year of publication
1997
Pages
2197 - 2200
Database
ISI
SICI code
0040-4039(1997)38:13<2197:SOMAUT>2.0.ZU;2-4
Abstract
The synthesis of microcolin analogs is described using an approach tha t could be of considerable practical interest for structure-activity s tudies on microcolin and related peptides. This synthetic pathway is m ore efficient than the methods reported to date, and allows the variat ion of the Xaa-pyrrolin-2-one unit of these molecules, which has been shown to be crucial for the biological activity. (C) 1997 Elsevier Sci ence Ltd.