A NEW APPROACH TO HMB-BACKBONE PROTECTION OF PEPTIDES - SYNTHESIS ANDREACTIVITY OF N-ALPHA-FMOC-N-ALPHA-(HMB)AMINO ACIDS

Authors
NICOLAS E PUJADES M BACARDIT J GIRALT E ALBERICIO F
Citation
E. Nicolas et al., A NEW APPROACH TO HMB-BACKBONE PROTECTION OF PEPTIDES - SYNTHESIS ANDREACTIVITY OF N-ALPHA-FMOC-N-ALPHA-(HMB)AMINO ACIDS, Tetrahedron letters, 38(13), 1997, pp. 2317-2320
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
13
Year of publication
1997
Pages
2317 - 2320
Database
ISI
SICI code
0040-4039(1997)38:13<2317:ANATHP>2.0.ZU;2-R
Abstract
The use of N-Fmoc-N-(Hmb)amino acids for the introduction of the Hmb b ackbone protection into peptides during solid-phase synthesis is descr ibed An efficient two step synthesis of these derivatives is reported and their coupling to the peptide chain is studied. (C) 1997 Elsevier Science Ltd.