UREASE-INDEPENDENT CHEMOTACTIC RESPONSES OF HELICOBACTER-PYLORI TO UREA, UREASE INHIBITORS, AND SODIUM-BICARBONATE

Authors
MIZOTE T YOSHIYAMA H NAKAZAWA T
Citation
T. Mizote et al., UREASE-INDEPENDENT CHEMOTACTIC RESPONSES OF HELICOBACTER-PYLORI TO UREA, UREASE INHIBITORS, AND SODIUM-BICARBONATE, Infection and immunity, 65(4), 1997, pp. 1519-1521
Citations number
19
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
4
Year of publication
1997
Pages
1519 - 1521
Database
ISI
SICI code
0019-9567(1997)65:4<1519:UCROHT>2.0.ZU;2-2
Abstract
Helicobacter pylori CPY3401 and an isogenic urease-negative mutant, HP T73, showed chemotactic responses to urea, flurofamide (a potent ureas e inhibitor), and sodium bicarbonate. Since urea and sodium bicarbonat e are secreted through the gastric epithelial surface and hydrolysis o f urea by urease on the bacterial surface is essential for colonizatio n, the chemotactic response of H. pylori may be crucial for its coloni zation and persistence in the stomach.