PURIFICATION AND CHARACTERIZATION OF A NA-INTERROGANS(,K+ ATPASE INHIBITOR FOUND IN AN ENDOTOXIN OF LEPTOSPIRA)

Authors
BURTH P YOUNESIBRAHIM M GONCALEZ FHFS COSTA ER FARIA MVC
Citation
P. Burth et al., PURIFICATION AND CHARACTERIZATION OF A NA-INTERROGANS(,K+ ATPASE INHIBITOR FOUND IN AN ENDOTOXIN OF LEPTOSPIRA), Infection and immunity, 65(4), 1997, pp. 1557-1560
Citations number
28
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
4
Year of publication
1997
Pages
1557 - 1560
Database
ISI
SICI code
0019-9567(1997)65:4<1557:PACOAN>2.0.ZU;2-6
Abstract
We showed previously that the glycolipoprotein fraction prepared from Leptospira interrogans inhibited the Na+,K+ ATPase enzyme purified fro m brain or kidney and in isolated nephron segments (M. Younes-Ibrahim, P. Burth, M. V. Castro Faria, B. Buffin-Meyer, S. Marsy, C. Barlet-Ba s, L. Cheval, and A. Doucet, C. R. Acad. Sci, Paris Ser, III 318:619-6 25, 1995). In the present communication, we have demonstrated that uns aturated fatty acids such as oleic and palmitoleic acids, which are ad sorbed to this fraction, are effective inhibitors of the enzyme.