Cranial mediastinal lesions were detected in three cats, associated wi
th respiratory impairment (case one), spontaneous pneumothorax (case t
wo) and myasthenia gravis (case three), respectively. On gross and his
tological examination, the first case was considered either a lymphang
ioma or a branchial cystic mass of the thymic region of the mediastinu
m; a cystic lesion was suggested by sonographic detection of multiple
anechoic cavitations within a circumscribed mass, while fine needle as
piration cytology excluded lymphosarcoma. The second case was diagnose
d histologically as a cystic thymoma, but: the third case was not exam
ined microscopically. The masses were amenable to surgical excision in
the first two cats, while this proved unnecessary in the third case b
ecause of resolution following treatment with dexamethasone. Corticost
eroid responsiveness was unhelpful in distinguishing between these ben
ign lesions and lymphosarcoma, as in two cases there was a partial or
complete response to dosing with prednisolone or dexamethasone. These
cases are presented to emphasise that conditions other than lymphosarc
oma can produce cranial mediastinal lesions in cats, and that the prog
nosis for surgical treatment of lymphangiomas, multilocular thymic cys
ts and cystic thymomas can be excellent.