Pd. Picon et al., ATHEROSCLEROSIS AND ACUTE ARTERIAL THROMBOSIS IN RABBITS - A MODEL USING BALLOON DESENDOTHELIZATION WITHOUT DIETARY INTERVENTION, Brazilian journal of medical and biological research, 30(3), 1997, pp. 415-417
Acute thrombosis can be induced in rabbits by a triggering protocol us
ing Russell's viper venom and histamine given after 8 months of a 1% c
holesterol diet and balloon desendothelization. In the present study,
we tested the hypothesis that aortic desendothelization performed 4 mo
nths before the triggering protocol without a high cholesterol diet is
a highly effective and less expensive way of producing arterial ather
osclerosis and thrombosis. Nineteen male New Zealand white rabbits on
a normal diet were studied. The control group (N = 9) received no inte
rvention during the 4-month observation period, while the other group
(N = 10) was submitted to aortic balloon desendothelization using a 4F
Fogarty catheter. At the end of this period, all animals were killed
48 h after receiving the first dose of the triggering treatment. Eight
of 10 rabbits (80%) in the balloon-trauma group presented platelet-ri
ch arterial thrombosis while none of the animals in the control group
had thrombus formation (P < 0.01). Thus, this model, using balloon des
endothelization without dietary manipulation, induces arterial atheros
clerosis and thrombosis and may provide possibilities to test new ther
apeutic approaches.