OBJECTIVE. We undertook this study to determine the CT findings of lip
omatous hypertrophy of the interatrial septum, an asymptomatic and und
errecognized benign proliferation of fat within the atrial septum. MAT
ERIALS AND METHODS. We retrospectively identified 12 cases of lipomato
us hypertrophy of the interatrial septum by searching the radiology re
cords at our institution from 1991 to 1995. We reviewed the CT scans o
f these patients to determine the distribution and morphology of fat w
ithin the interatrial septum.RESULTS. In ail patients with lipomatous
hypertrophy, a mass of fat attenuation extended from the coronary sinu
s to just above the level of the aortic root with relative sparing of
the fossa ovalis, which resulted in a dumbbell configuration. Average
dimensions were 7 cm for craniocaudal extent (range, 6-9 cm), 4.5 cm a
long the interatrial septum (range, 3.6-6.2 cm), and 2.7 cm perpendicu
lar to the septum (range, 1.5-4.8 cm), Increased epicardial fat was se
en on CT scans in 10 patients (83%). CT revealed mediastinal lipomatos
is in six patients (50%). No patients had undergone corticosteroid tre
atment or total parenteral nutrition. No electrocardiographic or funct
ional cardiac abnormalities were seen. CONCLUSION. On standard, high-r
esolution, and enhanced CT images, lipomatous hypertrophy of the inter
atrial septum is shown as a nonenhancing smoothly marginated homogenou
s dumbbell-shaped mass of fat attenuation confined to the interatrial
septum. These characteristic morphologic features allow confident diag
nosis and help differentiate this benign condition fi om other cardiac
masses.