DIGITAL ANOMALIES, MICROCEPHALY, AND NORMAL INTELLIGENCE - NEW SYNDROME OR FEINGOLD SYNDROME

We present four patients-two boys and their mother and an unrelated gi rl-with microcephaly, normal intelligence, and distal abnormalities, T he hand abnormalities are characterized by brachydactyly with radial c linodactyly of the fourth and fifth fingers, ulnar clinodactyly of the second fingers, and an increased space between the second and third f ingers associated with an abnormal palmar crease that extends to the u lnar border, The foot abnormalities include short toes with syndactyly of the fourth and fifth toes, The mother has normal intelligence, and her sons and the unrelated girl have normal development, Although sim ilar digital abnormalities, microcephaly, and normal intelligence were described by Feingold in patients with gastrointestinal atresia, we t hink that our patients' findings represent a different condition, The most likely mode of inheritance is autosomal dominant, The clinical re cognition of this syndrome will allow for appropriate genetic counseli ng as well as provision of information on natural history, i.e., norma l intelligence. (C) 1997 Wiley-Liss, Inc.